New research suggests that patients who stop using popular slimming jabs like semaglutide or tirzepatide can put back on reduced body mass far faster than those who end conventional lifestyle regimens.
Research printed in a prominent medical journal points out that while obese individuals frequently drop a large proportion of their total mass while on the medication, the weight is regained at an average rate of nearly a kilo each month after stopping.
"People buying these treatments need to be cognizant of the risk of quick rebound weight gain when the medication is stopped," cautioned lead investigator Dr. Susan Jebb.
Such speed of recovery means a return to original mass within about one and a half years.
Comparing Treatments
The analysis, which examined dozens of studies involving over 9,000 of patients, compared the outcomes of GLP-1 agonists with conventional dieting.
Researchers note that individuals who lose weight through lifestyle changes alone generally see a more gradual weight regain—around 0.1 kg a month—once they finish.
The Reason for the Quick Rebound
Nutrition scientists believe the way of the drugs explains the accelerated weight return.
These medications copy a body's own chemical called GLP-1, which helps regulate hunger.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the system to produce less of its own natural hormone, and could reduce sensitivity to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this hormone supplement leads to hunger is no longer kept in check, making overeating much more probable."
A Lifelong Issue?
The NHS recommend the injections for people with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
A number of clinicians argue that, given the likelihood of relapse, the therapy might need to be long-term.
This opinion is echoed by drug manufacturers, who note that the results "underscore the chronic character of obesity," similar to managing diseases like high blood pressure.
Patient Accounts
Individuals who have stopped the medication report a powerful resurgence of appetite.
"It felt as if a trigger activating and you become extremely hungry," recalled one woman.
This difficulty is worsened if individuals have not developed sustainable lifestyle or habit changes during therapy.
Significant Use
Survey data show that a significant number of adults in the UK have used weight-loss jabs in the past year, with interest being substantial.
- Adoption is higher among females than males.
- The 40s and 50s demographic shows the highest level of interest.
- Many access the drugs through private prescriptions rather than the NHS.
Ultimately, researchers stress that while the jabs are potent agents for shedding pounds, they are not a permanent cure and maintained weight loss hinges on ongoing lifestyle support.
